BroadEye: An Ophthalmology Podcast

Leading with Vision: Angela Bonfanti's Journey to Transforming Accessibility at CNIB

In this episode, we sit down with Angela Bonfanti, the first female CEO and President of the Canadian National Institute for the Blind (CNIB). Angela shares her personal and professional journey, the challenges and opportunities of leading a 106-year-old organization, and her vision for improving accessibility and inclusion for individuals with vision loss in Canada.

---

About the Guest

Angela Bonfanti, the CEO and President of CNIB, is a trailblazer in the accessibility and inclusion space. With over 13 years of dedicated service at CNIB in various leadership roles, Angela became the organization’s leader in 2023, marking her 13th anniversary with the institute. She brings a deeply personal connection to her work, having grown up witnessing her father's journey with vision loss due to Retinitis Pigmentosa. Angela's leadership is defined by her commitment to systemic change, grassroots advocacy, and empowering individuals with vision loss through innovative programs and community-driven solutions.

---

About the CNIB

The Canadian National Institute for the Blind (CNIB) is Canada’s leading organization dedicated to empowering people impacted by blindness and vision loss. Established in 1918, CNIB supports individuals across the country with programs focusing on education, employment, accessibility, and advocacy. From guide dog training to groundbreaking virtual services, CNIB aims to create a world without barriers for people living with vision loss. Under Angela Bonfanti's leadership, the CNIB continues to advance its mission of inclusivity and accessibility through collaboration and innovative strategies.

Revolutionizing Retinal Gene Therapy: A Conversation with Dr. Carlos Quezada-Ruiz

Dr. Carlos Quezada-Ruiz is a Vitreoretinal Surgeon and Assistant Professor of Ophthalmology at the Instituto de Oftalmologia Fundación Conde de Valenciana’s Retina Department in Mexico City. He also serves as the Senior Vice President of Clinical Research and Development and Therapeutic Area Head (Ophthalmology) at 4DMT, leading early- and late-stage clinical development teams focused on treating neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and geographic atrophy (GA).

In addition to his active clinical practice, Dr. Quezada-Ruiz has spent the past decade as a Drug Developer, beginning at Genentech–Roche. There, he worked on the Ophthalmology management team as Group Medical Director of Clinical Science (Product Development). During his tenure, he led the design, execution, and analysis of U.S. and global registrational trials for multiple retinal diseases, including the nAMD global clinical development program for VABYSMO, resulting in U.S. and worldwide approvals. He also led the global clinical science team for SUSVIMO, supporting its initial global filing, FDA approval, and launch in nAMD; successfully navigated the U.S. voluntary recall and commercial relaunch; and oversaw the phase 3 DR/DME registrational program through execution, readout, and filing with the FDA in early 2024. Previously, Dr. Quezada-Ruiz led Medical Affairs efforts for the U.S. launch of Lucentis Prefilled Syringe (PFS) and the myopic choroidal neovascularization indication for LUCENTIS.

Furthermore, Dr. Quezada-Ruiz contributed to diversity and inclusion strategies in the Ophthalmology Franchise—such as the AAO MOM program—and advanced personalized healthcare in retina at Genentech by helping design and develop predictive models that use machine learning and large language models to support both drug development and clinical practice.

Dr. Quezada-Ruiz is a Fellow of the American Society of Retina Specialists, with over 13 years of clinical practice and research in vitreoretinal diseases and surgery. He earned his M.D. from Universidad Autónoma de Coahuila in his hometown of Torreón, Mexico. He completed fellowships in Vitreoretinal Surgery, Ocular Pathology Research, and Vitreoretinal Surgery Research at Universidad Nacional Autónoma de México, McGill University, and the California Retina Research Foundation, respectively. In 2023, he completed an Executive Education program (CIBE) at Columbia Business School.

His accolades include the 2023 Roche Award of Excellence in recognition of outstanding contributions to Roche Pharmaceuticals (“Vabysmo and Beyond”), Genentech’s 2023 Medical Excellence Award, the 2019 American Society of Retina Specialists Senior Honor Award, the 2016 ASRS Honor Award, the 2013 Gillingham Pan-American Fellowship by the Pan-American Association of Ophthalmology and The Retina Research Foundation of Houston, Texas, and the 2013 Leonard Ellen Ocular Pathology Award by the Royal Victoria Hospital Foundation.

On a personal note, Dr. Quezada-Ruiz is married to Cecy—formerly a marketing specialist at The Coca-Cola Company—and they have three children and a white Labrador, Mia, who is blind from retinal dystrophy. He is also a retired martial artist, philosopher, and health enthusiast.

About 4DMT
4DMT is a clinical-stage genetic medicines company focused on harnessing the full potential of genetic therapies for large market diseases, particularly in ophthalmology (wet AMD and DME) and pulmonology (cystic fibrosis lung disease).

Therapeutic Vector Evolution (TVE): 4DMT’s proprietary vector platform leverages the Nobel Prize–winning technology of directed evolution to create customized viral vectors. This approach propels a diverse product pipeline aimed at revolutionizing medicine with potentially curative therapies for millions of patients.

 

Leading Change in Eye Health - A Conversation with Jason Menzo (FFB)

In this episode, we sit down with Jason Menzo, CEO of the Foundation Fighting Blindness, to discuss his unique journey from the pharmaceutical industry to leading one of the world’s most impactful organizations in eye health. Jason shares insights on his career transition into the nonprofit sector and his commitment to advancing the Foundation’s mission. We explore groundbreaking initiatives like My Retina Tracker, a resource bridging patients to clinical trials, and dive into the Foundation’s bold vision for future treatments, including the potential of eye transplants. Plus, hear how the Foundation is fueling innovation by investing in promising small eye care companies and funding research to combat inherited retinal diseases.

Season 2 Premiere: Reconnecting and Exploring New Horizons with Shawn and Bruno

In the exciting launch of Season 2 of the Broad Eye podcast, we explore the latest developments in eye care and share our personal journeys over the past couple of years. This season will focus on highlighting inspiring individuals and organizations that are making significant strides in ophthalmology, aiming to bridge knowledge gaps and enhance access to eye health.

 

Bruno discusses his innovative project, "Eye Station," a free eye screening initiative located in a busy mall in Brazil, designed to provide easier access to eye care screenings and education for the public. This social project aims to bridge the gap in eye care accessibility that the public sector struggles to meet, allowing individuals to receive essential screenings without the barriers of cost or inconvenience. 

 

Meanwhile, Shawn shares his involvement with several non-profit organizations, including the Canadian National Institute for the Blind (CNIB) and the Foundation Fighting Blindness (FFB), as well as his exciting new book project co-authored with Paralympic athlete and educator Victoria Nolan. This book aims to serve as a comprehensive resource for individuals newly diagnosed with vision loss, filling a crucial gap in available information.

 

Together, we reflect on our experiences and the challenges we've faced, setting the stage for a season filled with compelling stories and expert insights that underscore the transformative power of accessible eye health.

Navigating and overcoming challenges of everyday life as a visually impaired person - Dagmar Jamieson

In this episode our guest is Dagmar Jamieson, a mentor and life coach at CNIB. We discuss the challenges in everyday life as a visually impaired person, how that affects our social skills, are there any professional limitations and how does Dagmar cope with all those challenges.

Improving the way we manage glaucoma patients - Ariel Cao

Ariel Cao is the president/CEO and co-founder of Injectsense. We talked about the current challenges in the management of patients with glaucoma, still one of the major causes of blindness worldwide. Cao and his team developed an implantable intraocular device that can continuously monitor intraocular pressure. By providing accurate, clinically actionable information, physicians will be able to individualize therapeutic interventions for each patient, properly assess the effectiveness of glaucoma therapy, and ultimately avoid blindness. 

Differences between generic and branded eye drops - Dr. Andrew Meagher

In this episode, we review differences in regulatory requirements for branded and generic therapeutic agents, and how these differences can manifest in eye care. Dr. Andrew Meagher sheds light on the subject using IOP-lowering glaucoma drops as an example.

Drawing on his experience in the clinic and keen attention to scientific detail, Dr. Meagher shares knowledge as Associate Professor at the Salus University, School of Optometry.

Instilling the call for humanitarian service - Dr. Bradley Farris

In this episode, we had the chance to talk with Dr. Farris about his charitable work in eye care both in the United States and internationally. For the past 20 years, he has led a team annually from Dean McGee Eye Institute to develop academic exchange and work with the local residency-training programs in China.  He has done the same in Africa for the past 11 years.

Dr. Farris is the 2021 recipient of the Outstanding Humanitarian Service Award by the American Academy of Ophthalmology and Professor Emeritus of Ophthalmology at the University of Oklahoma and Dean McGee Eye Institute. 

From the operating room to the C-suite in pharma - Dr. Jay Duker

Dr. Duker is an accomplished ophthalmologist, that is now the Chief Operating Officer of EyePoint Pharma, a biotech company that develops sustained-release medications to treat serious ocular disorders. We talked about his career path and what motivated him to move from a clinical to an executive position. For the 21 years before he took the COO position at EyePoint, Dr. Duker was the Director of the New England Eye Center (NEEC) and Professor and Chair of the Department of Ophthalmology at Tufts Medical Center, Tufts University School of Medicine in Boston, Massachusetts. Dr. Duker received his medical degree from Jefferson Medical College. He completed a residency and fellowship in vitreoretinal diseases and ocular oncology at the Wills Eye Hospital.

Art beyond what we can see - Dr. John Kennedy

What might come as a surprise to most people is that the visually impaired can draw!

Dr. Kennedy is a Professor of Psychology at the University of Toronto and is especially interested in the theory of pictures drawn by people who are blind. The key idea is that lines in outline drawings mean the same thing to the sighted and people who are blind -- edges of surfaces, such as profiles of people and corners of cubes. These shapes are understood via touch as well as vision. We also talked about how drawing kits are now made available free to all children who are blind in the US and his book on the topic: Drawing and the Blind: Pictures to Touch.